Regulation of hly Expression in Listeria monocytogenes by Carbon Sources and pH Occurs through Separate Mechanisms Mediated by PrfA
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Regulation of hly expression in Listeria monocytogenes by carbon sources and pH occurs through separate mechanisms mediated by PrfA.
Expression of the PrfA-controlled virulence gene hly (encoding the pore-forming cytolysin listeriolysin) is under negative regulation by readily metabolized carbon sources in Listeria monocytogenes. However, the hyperhemolytic strain NCTC 7973 exhibits deregulated hly expression in the presence of repressing sugars, raising the possibility that a defect in carbon source regulation is responsibl...
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8 1 Département de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique9 Hôpitaux de Paris, Université Paris Descartes, France 10 2 Centre National de Référence des Listeria, World Health Organization Collaborating Centre 11 for Foodborne Listeriosis, Institut Pasteur, Paris, France. 12 3 Actual Adress: Laboratoire de Microbiologie-Hygiène, Centre Hospitalier de Versailles, Le 13 ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1998
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.66.8.3635-3642.1998